Urinary 5-hydroxyindoleacetic acid (5-HIAA) excretion before and during cisplatin chemotherapy in patients with intrathoracic malignancy

Psychopathology and 5-hydroxyindoleacetic acid excretion.

CONSIDERABLE indirect evidence, associating serotonin with central nervous system function and the actions of important psychotropic drugs, led to suggestions192 of a relationship between serotonin metabolism and schizophrenia. Despite considerable effort, experimental support for this suggestion has been inconclusive. Among studies in this area are those on quantitative excretion, and variabil...

Daily cyclic changes in the urinary excretion of 5-hydroxyindoleacetic acid in patients with carcinoid tumors.

BACKGROUND Vasoactive peptides produced by neuroendocrine tumors can induce characteristic symptoms of the carcinoid syndrome (flushing, diarrhea, and wheezing). To what extent external factors provoke these symptoms and how excretion of 5-hydroxyindoleacetic acid (5-HIAA), the degradation product of serotonin, varies throughout the day remain unknown. In this study, we investigated whether sym...

Urinary excretion of 5-hydroxyindoleacetic acid, serotonin and 6-sulphatoxymelatonin in normoserotonemic and hyperserotonemic autistic individuals.

OBJECTIVE A substantial proportion of individuals with autism have elevated levels of platelet serotonin (5-HT). We examined whether platelet hyperserotonemia is associated with increased gut 5-HT synthesis, altered 5-HT catabolism or altered melatonin production. METHODS Urinary excretion of 5-hydroxyindoleacetic acid (5-HIAA) and 5-HT was compared in 10 normoserotonemic and 10 hyperserotone...

Urinary 5-hydroxyindoleacetic acid by HPLC with electrochemical detection.

A Method for Quantitative Extraction of Urinary 5-hydroxyindoleacetic Acid.

HE QUANTITATIVE ESTIMATION of urinary 5-hydroxyindoleacetic acid (5-HIAA) has attained clinical importance with increasing interest in indole metabolism. Urinary 5-HIAA levels have largely been determined by the use of an extraction procedure described by Udenfriend et al. (1). The author has found, as have others (2), that this method produces inconsistent results on varying dilutions of a giv...